Phase IIa Clinical Trial Results Relating To CK-1827452 In Patients With Ischemic Cardiomyopathy And Angina
Cytokinetics, Incorporated (NASDAQ: CYTK) announced today top-line results from a Phase IIa clinical trial evaluating the safety of CK-1827452 in patients with ischemic cardiomyopathy and angina.  The primary safety endpoint was defined as stopping an exercise test during treatment with CK-1827452 (versus placebo) due to unacceptable angina at an earlier exercise stage than at baseline.


feel a pressure type pain in the head, often behind the eyes or in the sinuses. They may describe a band-like sensation, or a heavy-headed feeling, that may be accompanied by symptoms of poor concentration or ‘foggy’ headedness, poor appetite or heavy limbs. These Damp headache patients are walking barometers, and commonly report that the headache is worse with weather changes, particularly during cloudy or rainy weather. Acupressure practitioner reports that pressing for 60 seconds on the web space between the forefinger and thumb of the dominant hand erases headache in patients with migraine and tension-type headaches. The specific spot pressed should be the most tender point in the web area. The patient should then lie down for about 15 minutes. Acupuncture, hypnosis and biofeedback are all alternative ways to control pain. Acupuncture involves the insertion of tiny sterile needles, slightly thicker than a human hair, at specific points on the body.

Acupuncture refers broadly to a group of procedures that stimulate the skin. Acupuncture is widely used to prevent migraine attacks, but the available evidence of its benefit is scarce. Acupuncture (up to 15 sessions over 12 weeks) was compared with metoprolol (a standard migraine prophylaxis medication). Acupuncture use has been reported for treating and alleviating a variety of ocular conditions. One randomized controlled double-masked study was found that examined the use of acupuncture for dry eye. Needles, 36-gauge, were inserted subcutaneously without penetrating the cartilage, and left in place 30 minutes without any manipulation or stimulation. The total number of treatments ranged from 2-11; the average number was 5. Frequency of treatment was 2-3 times a week, with the number of treatments determined by patient requirements. Acupuncture was no more effective than sham acupuncture in reducing migraine headaches although both interventions were more effective than a waiting list control. Acupuncture is not only effective for migraine headaches, but also works very well with tension headaches, cluster headaches, post-traumatic headaches, and disease-related headaches that might be due to sinus problems, high blood pressure or sleeping disorders. The greatest advantage of acupuncture over Western medicine is that it does virtually no harm. Some medications can have serious side effects and can (in some instances) actually lead to patients experiencing a "rebound" headache.

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Juliet Cohen writes articles on health doctor and health care. She also writes articles on health disorders.